Methods for Building Atomic Models of Protein Molecules and Determining Drug Candidates Using MGST1

摘要

Methods for building an atomic model of a protein molecule comprising: (a) identifying a protein molecule with at least 20% sequence identity with Microsomal Glutathione Transferase 1 (MGST1) and (b) utilizing the atomic coordinates of MGST1 to obtain an atomic model of the identified protein molecule and methods for determining a drug candidate compound that interacts with members of the MAPEG superfamily, in particular MGST1 are also provided.