首页> 外国专利> RAPIDLY SOLUBLE GRANULATE OF BROMOHEXINE OR BROMOHEXINE HYDROCHLORIDE, METHOD FOR THE PRODUCTION OF SAID GRANULATE AND THE USE THEREOF

RAPIDLY SOLUBLE GRANULATE OF BROMOHEXINE OR BROMOHEXINE HYDROCHLORIDE, METHOD FOR THE PRODUCTION OF SAID GRANULATE AND THE USE THEREOF

机译:溴己胺或氢溴酸溴己碱的速溶颗粒,生产所述颗粒的方法及其用途

摘要

The invention relates to a rapidly soluble granulate that is obtained by (a) the production of an aqueous granulation liquid containing at least one binding agent and (b) the spraying of the granulation liquid obtained in step (a) onto a fluidised bed in a countercurrent at a constant supply air temperature onto a support containing at least one carbohydrate, whereby bromohexine or bromohexine hydrochloride and citric acid are introduced, independently of one another into the granulation liquid and/or onto the support. The invention permits for the first time the provision of a water-soluble granulate containing bromohexine or bromohexine hydrochloride as the active ingredient. Said inventive granulate is water-soluble, despite the fact that the bromohexine or bromohexine hydrochloride is practically insoluble in water, i.e. the granulate dissolves completely in water within a few minutes and releases the active ingredient in its entirety.
机译:本发明涉及一种速溶颗粒,其通过以下方式获得:(a)生产包含至少一种粘合剂的水性造粒液体,以及(b)将步骤(a)中获得的造粒液体喷雾到在塔中的流化床上。在恒定的供应空气温度下逆流至含有至少一种碳水化合物的载体上,由此将溴己己或盐酸溴己己和柠檬酸彼此独立地引入造粒液和/或载体中。本发明首次允许提供含有溴己己或盐酸溴己己作为活性成分的水溶性颗粒。所述本发明的颗粒是水溶性的,尽管事实上溴己己或盐酸溴己己实际上不溶于水,即,该颗粒在几分钟之内完全溶解于水中,并全部释放出活性成分。

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