ALKYNYL BASED DERVATIVES OF BENZOPHENONE AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

摘要

Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula wherein the substituents are as defined in the following table tables id="TABLE-US-00001" num="00001" table frame="none" colsep="0" rowsep="0" tgroup align="left" colsep="0" rowsep="0" cols="6" colspec colname="offset" colwidth="14pt" align="left"/ colspec colname="1" colwidth="35pt" align="left"/ colspec colname="2" colwidth="35pt" align="left"/ colspec colname="3" colwidth="35pt" align="left"/ colspec colname="4" colwidth="28pt" align="left"/ colspec colname="5" colwidth="70pt" align="left"/ THEAD ROW ENTRY/ entry namest="offset" nameend="5" align="center" rowsep="1"/ /ROW ROW ENTRY/ ENTRYRSUP1/SUP/ENTRY ENTRYRSUP2/SUP/ENTRY ENTRYRSUP4/SUP/ENTRY ENTRYRSUP5/SUP/ENTRY ENTRYRSUP8a/SUP/ENTRY /ROW ROW ENTRY/ entry namest="offset" nameend="5" align="center" rowsep="1"/ /ROW /THEAD TBODY VALIGN="TOP" ROW ENTRY/ ENTRYF/ENTRY ENTRYCFSUB3/SUB/ENTRY ENTRYMe/ENTRY ENTRYH/ENTRY ENTRY-OH/ENTRY /ROW ROW ENTRY/ ENTRYF/ENTRY ENTRYCFSUB3/SUB/ENTRY ENTRYCl/ENTRY ENTRYH/ENTRY ENTRY-OH/ENTRY /ROW ROW ENTRY/ ENTRYF/ENTRY ENTRYCFSUB3/SUB/ENTRY ENTRYMe/ENTRY ENTRYH/ENTRY ENTRY-O-CHSUB2/SUBCOSUB2/SUBH/ENTRY /ROW ROW ENTRY/ ENTRYCl/ENTRY ENTRYCN/ENTRY ENTRYCl/ENTRY ENTRYH/ENTRY ENTRY-OH./ENTRY /ROW ROW ENTRY/ entry namest="offset" nameend="5" align="center" rowsep="1"/ /ROW /TBODY /TGROUP /TABLE /TABLES