new composition for transdermal and / or transmukosalen wirkstoffanwendung with suitable therapeutic levels

摘要

The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH3-(CH2)n-CH2OH or saturated fatty acid CH3-(CH2)n-CH2COOH wherein n is an integer number 8 + 22, preferably 8 + 12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH3(CnH2(n-1))-OH or CH3(CnH2(n-1))-COOH wherein n is an integer number 8 + 22, b) a ternary vehicle or carrier consisting of a C1 + C4 alkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol.