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Itpase gene polymorphisms associated with adverse drug reactions to azathioprine
Itpase gene polymorphisms associated with adverse drug reactions to azathioprine
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机译:与硫唑嘌呤药物不良反应相关的Itpase基因多态性
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摘要
The present invention provides methods for predicting a patient's risk of an adverse drug reaction to a thiopurine drug such as AZA or 6-MP by genotyping the patient for a polymorphism in the gene encoding ITPase (ITPA). The present invention also provides methods for predicting a patient's risk of an adverse drug reaction to a thiopurine drug by determining a level of ITPase activity of ITP in a sample from the patient. The present invention further provides methods for optimizing therapeutic efficacy in a patient receiving a thiopurine drug by determining whether the patient should be given an alternative, drug based on the presence or absence of a polymorphism in the ITPA gene.
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