Labeled peptides, and processes and intermediates useful for their preparation

摘要

The invention provides intermediates and methods that allow for site-specific modification of peptides after synthesis. Accordingly, functional molecules can be selectively linked to a peptide to provide a peptide conjugate having altered biological, chemical, or physical properties. For example, functional molecules (e.g. biophysical probes, peptides, polynucleotides, and therapeutic agents) can be linked to a peptide to provide a peptide conjugate having differing and useful properties. The invention also provides a compound of formula (III):; wherein:R⁶ is a peptide;X is a direct bond or a linking group;R⁷ is hydrogen, (C₁-C₆)alkyl, an amino protecting group, or a radical comprising one or more aminooxy groups;Y is a direct bond or a linking group; andD is a functional molecule.