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compound or a salt, prodrug or solvate thereof, use of a compound method for treating glk-mediated diseases, and process for the preparation of a compound

机译:化合物或其盐,前药或溶剂化物,该化合物在治疗glk介导的疾病中的用途,以及制备该化合物的方法

摘要

COMPOUND OR A SALT, PRODUCT OR SOLVATE THEREOF, USE OF A COMPOUND METHOD TO TREAT GLK MEDIATED DISEASES, AND PROCESS FOR PREPARING A COMPOUND. Compounds of Formula (I) are described wherein: R is hydroxymethyl; R¬ 2¬ is selected from -C (O) NR¬ 4¬ R¬ 5¬, SO ~ 2 ~ NR¬ 4¬R¬ 5¬, 5 (O), R¬ 4¬ and HET-2; HET-1 is an optionally substituted 5- or 6-membered C-linked heteroaryl ring; HET -2 is an optionally substituted 4- or 5- membered C or N-linked heterocyclyl ring; R¬ 3¬ is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R¬4¬ is selected from, for example, hydrogen, optionally substituted (1-4C) alkyl and HET-2; R¬5¬ is hydrogen or (1-4C) alkyl; or R¬4¬ and R¬5¬, together with the nitrogen atom to which they are attached, may form a heterocyclyl ring system as defined by HET-3; HET-3 is, for example, an optionally substituted, 4-, 5- or 6-membered saturated or particularly unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, prodrug or solvate thereof. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.
机译:化合物或盐,产品或溶剂化物,使用化合物方法治疗GLK介导的疾病,以及制备化合物的过程。描述了式(I)的化合物,其中:R为羟甲基; R 2选自-C(O)NR 4〜R 5,SO 2〜NR 4〜R 5,5(O),R 4以及HET-2; HET-1是任选取代的5-或6-元C-连接的杂芳基环; HET -2是任选取代的4或5元C或N-连接的杂环基环; R 3-选自卤素,氟甲基,二氟甲基,三氟甲基,甲基,甲氧基和氰基; R 4-选自例如氢,任选取代的(1-4C)烷基和HET-2; R 5-为氢或(1-4C)烷基; R 4和R 5与它们所连接的氮原子一起可以形成如HET-3所定义的杂环基环系统; HET-3是例如任选取代的4、5或6元饱和或特别是不饱和的杂环基环; p(在每次出现时独立地)为0、1或2; m为0或1; n为0、1或2;假设当m为0时,n为1或2;或其盐,前药或溶剂化物。还描述了它们作为GLK活化剂的用途,包含它们的药物组合物以及其制备方法。

著录项

  • 公开/公告号BRPI0511808A

    专利类型

  • 公开/公告日2008-01-15

    原文格式PDF

  • 申请/专利权人 ASTRAZENECA AB;

    申请/专利号BR2005PI11808

  • 申请日2005-06-01

  • 分类号C07D277/46;A61K31/415;A61K31/426;A61P3/04;A61P3/10;C07D231/40;C07D285/08;C07D403/12;C07D413/12;C07D417/12;C07F7/18;

  • 国家 BR

  • 入库时间 2022-08-21 20:08:47

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