Membrane or matrix for controlling permeation rate of medicaments and containing composition based on siloxane elastomers and process for preparing such elastomer

摘要

The present invention relates to a membrane or matrix for controlling the permeation rate of a medicament, wherein said membrane or matrix comprises a siloxane-based elastomer composition, which comprises at least one elastomer and possibly a crosslinked polymer. The elastomer composition comprises poly(alkylene oxide) groups, and the poly(alkylene oxide) groups are present in the elastomer or the polymer as alkoxy-terminated grafts of polysiloxane units, or as blocks, the said grafts or blocks being linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms. The invention also relates to methods for the preparation of the elastomer composition to be used in said membrane or matrix. There is also disclosed a process for the preparation of the above-described siloxane-based elastomer which comprises poly (alkylene oxide) groups and is intended for use in a membrane or matrix controlling the permeation rate of drugs, characterized in that a) a vinyl-functional polymer component and a hydride functional component are crosslinked in the presence of a catalyst, or b) a polymer component is crosslinked in the presence of a peroxide catalyst.