TRIPLE-TARGETING, CHIRAL, BROAD-SPECTRUM ANTIMICROBIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES , THEIR PREPARATION, COMPOSITIONS AND USE AS MEDICAMENTS

摘要

A compound selected from the group consisting of: 4-Amino-3,3-dimethylpiperidine or optical enantiomers of; 4-Methylamino-3,3-dimethylpiperidine or optical enantiomers thereof; 4-Ethylamino-3l3-dimethylpiperidine or optical enantiomers thereof; 4-Cyclopropylamino-3,3-dimethylpiperidine or optical enantiomers thereof; 4-Dimethylamino-3,3-dimethylpiperidine or optical enantiomers thereof; 4-Benzylamino -3,3-dimethylpiperidine or optical enantiomers thereof; 4-Acetylamino-3)3-dimethylpiperidine or optical enantiomers thereof; 4-Carbethoxyamino-3,3-dimethylpiperidine or optical enantiomers thereof; (±)-4-t-Butyloxycarbonylamino-3,3-dimethylpiperidine; (+)-4-t-Butyloxycarbonylamino-3,3-dimethylpiperidine; (-)-4-t-Butyloxycarbonylamino-3,3-dimethylpiperidine; 4-Benzyloxycarbonylamino-3,3-dimethylpiperidine or optical enantiomers thereof; 4-Amino-1-benzyl-3,3-dimethylpiperidine or optical enantiomers thereof; 4-Amino-1-carbethoxy-3,3-dimethylpiperidine or optical enantiomers thereof; 4-Amino-1-t-butyloxycarbonyl-3,3-dimethylpiperidine or optical enantiomers thereof; (+)- 4-Amino-1 -benzyloxycarbonyl-3,3-dimethylpiperidine; (+)- 4-Amino-1 -benzyloxycarbonyl-3,3-dimethylpiperidine; (-)- 4-Amino-1 -benzyloxycarbonyl-3,3-dimethylpiperidine; 4-Amino-1-carbethoxy-3-methylpiperidine; 4-Amino-3,5-diethyl-3-methylpiperidine; 4-Amino-1-carbethoxy-3,5-dimethylpiperidine; 4-Amino-1-benzyl-3,5-diethyl-3-methylpiperidine; 4-Amino-3,5-dimethyl-3-ethylpiperidine; 4-Amino-1-benzyl-3,5-dimethyl-3-ethylpiperidine; 4-Amino-3,5-diethylpiperidine; 4-Amino-1-benzyl-3,5-diethylpiperidine; 4-Amino-3,3,5-trimethylpiperidine; 4-Amino-3,3-diethylpiperidine; 4-Amino-1-benzyl-3,3-diethylpiperidine; 4-Amino-3,5-dimethylpiperidine; Mixture of isomers of 4-amino-1-carbethoxy-3,5-dimethylpiperidine; 4-Amino-3-ethyl-3-methylpiperidine; 4-Amino-1-benzyl-3-ethyl-3-methylpiperidine; 4-Acetylamino-1 -benzyl-3,3-dimethyl piperidine; cis or frans-4-t-Butyloxycarbonylamino-1-benzyl-3-methylpiperidine; cis-4-t-Butyloxycarbonylamino-3-methylpiperidine; trans-4-t-Butyloxycarbonylamino-3-methylpiperidine; 1 -Benzyl-4-carbethoxyamino-3,3-dimethyl piperidine; 4-Benzyloxycarbonylamino-3,3-dimethylpiperidine; 1-Benzyl-4-cyclopropylarnino-3-ethyl-3-methylpiperidine; 1-Benzyl-4-methylamino-3-ethyl-3-methylpiperidine; cis or frans-4-t-Butyloxycarbonylamino-1 -benzyl-3-methylpiperidine; 1-Benzyl-4-dimethylamino-3-ethyl-3-methylpiperidine; 4-Carbethoxyamino-3,3-dimethylpiperidine; 1-Carbethoxy-4-ethylamino-3-methylpiperidine; 4-Cyclopropylamino-3-methylpiperidine; 1-Carbethoxy-4-cyclopropylamino-3-methylpiperidine; 1-Carbethoxy-4-dimethylamino-3-methylpiperidine; 4-Cyclopropylamino-3-ethylpiperidine; 4-Cyclopropylamino-3-ethyl-3-methylpiperidine; 4-Cyclopropylamino-3,5-dimethylpiperidine; 4-Dimethylamino-3-ethylpiperidine; 4-Dimethylamino-3-methylpiperidine; 4-Dimethylamino-3,5-dimethylpiperidine; 4-Dimethylamino-3-ethyl-3-Methylpiperidine; 4-Methylamino-3-methylpiperidine; 4-Ethylamino-3-methylpiperidine; 4-Methylamino-3-ethylpiperidine; 4-Methylamino-3-ethyl-3-methylpiperidine; 4-Methylamino-3,5-dimethylpiperidine; and 4-Ethylamino-3,5-dimethylpiperidine.