PROFILACTIC AND THERAPEUTIC TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFECTIOUS DISEASES WITH COMPOUNDS BASED ON MONOSACARIDS.

摘要

The use, in the manufacture of a medicament for the treatment of an infectious disease, an autoimmune disease or an allergic condition by monotherapy (that is, in the absence of an exogenous antigen), of one or more compounds having the formula: (See formula) and pharmaceutically acceptable salts thereof, wherein X is a member selected from the group consisting of -O- and -NH-; R 1 and R 2 are, each of them, an independently selected member, from the group consisting of acyl (C2-C24); R 3 is a member selected from the group consisting of -H and -PO3R 11 R 12, R 11 and R 12, each being an independently selected member, from the group consisting of -H and (C1-) alkyl C4); R 4 is a member selected from the group consisting of -H, -CH3 and -PO3R 13, R 14, R 13 and R 14, each being an independently selected member, from the group consisting of -H and (C1-C4) alkyl; and Y is a remainder of the formula: (See formula) in which the subscripts n, m, p and q are, each independently, an integer from 0 to 6; R 5 is an acyl group (C2-C24); R 6 and R 7 are members independently selected from the group consisting of H and CH3; R 8 and R 9 are members independently selected from the group consisting of H, OH, (C1-C4) alkoxy, -PO3H2, -OPO3H2, -SO3H, -OSO3H, -NR 15 R 16, -SR 15, - CN, -NO2, -CHO, -CO2R 15, -CONR 15 SR 16, -PO3R 15 R 16, -OPO3R 15 R 16, -SO3R 15 and -OSO3R 15, R 15 and R 16 being each member independently selected, from the group consisting of H and (C1-C4) alkyl; and Z is -O- or -S-; with the proviso that when R 3 is -PO3R 11 R 12, R 4 is different from -PO3R 11 3R 14.