DESIGN OF INTERFERON-INDUCIBLE PROTEIN-10 (IP-10 OR CXCL10) CHEMOKINE ANALOGS FOR THE TREATMENT OF HUMAN DISEASES

摘要

This invention is directed to peptide analogs of interferon-inducible protein-10(IP-10 or CXCL10) chemokine that bind to the CXCR3 receptor or any otherreceptor inwhich IP-10 analogs can bind to as a ligand, such that the analogs can bedesigned toserve as agonists or antagonists of IP-10 chemokine. The analogs can be usedto prevent,treat, or ameliorate the symptoms of, a disease.