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ASSAYS FOR DETECTING NATIVE-STATE PROTEINS AND IDENTIFYING COMPOUNDS THAT MODULATE THE STABILITY OF NATIVE-STATE PROTEINS
ASSAYS FOR DETECTING NATIVE-STATE PROTEINS AND IDENTIFYING COMPOUNDS THAT MODULATE THE STABILITY OF NATIVE-STATE PROTEINS
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机译:检测天然蛋白并鉴定可调节天然蛋白稳定性的化合物的测定
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摘要
This invention relates to assays for detecting native-state proteins and to screening methods to identify compounds that modulate the stability of the native-state of proteins. Compounds identified by such screens can be used to treat diseases associated with protein misfolding, such as Alzheimer's Disease, familial amyloidotic polyneuropathies, and lysosomal storage diseases.
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