A Printed Circuit Board PCB provided with several pairs (P1; P2) of parallel wires (1a, 1b; 2a, 2b) carrying differential signals and following a same path from a start area (A) to an end area (B) on the PCB. The wires (1a, 1b) of at least one (P1) of the differential pairs are constituted by several consecutive sections (S1 to S5) and between each consecutive sections, the two wires of the pair are twisted on the PCB. In a first implementation of the invention, the two wires of the differential pair are located on a same layer (L1) of the PCB. In that case, a first (1a) of the two wires crosses the second wire (1b) by means of a bypass or via (V1 - V4) on a second layer (L2) of the PCB, alternatively between each consecutive sections (S1 - S5). In a variant or second implementation of the invention, the first wire (1a) and the second wire (1b) of a same pair (P1) are located on distinct layers (L1, L2) of said PCB. in that case, each wire changes of layer at each consecutive section intersection.
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