HUMAN RIBONUCLEASE WITH INHIBITING AFFINITY OF REDUCED RIBONUCLEASE.

摘要

A designed ribonuclease of the RNase A superfamily, which has at least one amino acid substitution in a loop region functionally equivalent to amino acid residues 85-94 of bovine pancreatic RNase A, designed ribonuclease that has a reduced binding affinity for the Ribonuclease inhibitor, and modified ribonuclease that preserves ribonucleolytic activity and whose modification provides a steric or electrostatic impediment to binding by the ribonuclease inhibitor.