HYBRID POLYPEPTIDES COMPRISING GBS-80 AND SPB1 PROTEINS OF STREPTOCOCCUS

摘要

GBS antigens GBS-80 and Spb1 are expressed in a single polypeptide chain,preferably with Spb1 upstream ofGBS-80. Thus the invention provides a polypeptide comprising an amino acidsequence NH2-W-X-L-Y-Z-CO2H, wherein: X is aSpb1 sequence; L is an optional linker; Y is a GBS-80 sequence; W is anoptional N-terminal sequence; and Z is an optionalC-terminal sequence.