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BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS
BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS
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机译:苯并异唑衍生物用作钾通道调节剂,用于治疗E.G.呼吸系统疾病,癫痫和惊厥
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摘要
This invention relates to novel benzisoxazole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels e.g. a respiratory disease, epilepsy or convulsions. X represents a subsituent selected from the group consisting of CO-NR'R'', CO-O-R', CO-NH-S, CO-NH-SO2R''', CO-NH-C=N, SO2-NR'R'', 2,3-dihydro-1-H-tetrazol-5-yl and [1, 2, 4]oxadiazolidin-5-one; wherein R' and R'', independently of each other, represent hydrogen or alkyl or phenyl; and R''' represents alkyl, cycloalkyl, haloalkyl or phenyl, which phenyl may optionally be substituted one or more times with substituents selected from halo, trifluoromethyl, trifluoromethoxy, cyano and nitro.
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