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BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS
BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS
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机译:苯并异唑衍生物用作钾通道调节剂,用于治疗E.G.呼吸系统疾病,癫痫和惊厥
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摘要
This invention relates to novel benzisoxazole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels e.g. a respiratory disease, epilepsy or convulsions. X represents a substituent selected from the group consisting of CONRR, COOR, CONHS, CONHSO2R, CONHCN, SO2NRR, 2,3-dihydro-1-H-tetrazol-5-yl and [1,2,4]oxadiazolidin-5-one; wherein R and R, independently of each other, represent hydrogen or alkyl or phenyl; and R represents alkyl, cycloalkyl, haloalkyl or phenyl, which phenyl may optionally be substituted one or more times with substituents selected from halo, trifluoromethyl, trifluoromethoxy, cyano and nitro.
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机译:本发明涉及新型的苯并异恶唑衍生物,它们被发现是钾通道的有效调节剂,因此,它们是治疗多种疾病或失调的有价值的候选物,如对钾通道的调节有反应的那些。呼吸系统疾病,癫痫或抽搐。 X表示选自CONRR,COOR,CONHS,CONHSO2R,CONHCN,SO2NRR,2,3-二氢-1-H-四唑-5-基和[1,2,4]恶二唑烷-5-酮的取代基;其中R 1和R 2彼此独立地表示氢或烷基或苯基; R 1代表烷基,环烷基,卤代烷基或苯基,其中苯基可任选地被选自卤素,三氟甲基,三氟甲氧基,氰基和硝基的取代基取代一次或多次。
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