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Methods and compositions for regulating protein-protein interactions
Methods and compositions for regulating protein-protein interactions
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机译:调节蛋白质-蛋白质相互作用的方法和组合物
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摘要
The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothrenonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.
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