PYRIMIDINE DERIVATIVES AND THEIR APPLICATION AS P2Y12 RECEPTOR ANTAGONISTS

摘要

1. A compound selected from the group consisting of compounds of the following formula I:! ! where R1 is phenyl optionally substituted 1-3 times with substituents, each of which is independently selected from the group consisting of halogen, methyl, methoxy, trifluoromethyl and trifluoromethoxy; ! W is a single bond, and R2 is alkyl, haloalkyl, cyano, hydroxyalkyl, hydroxyalkyl substituted on the alkyl chain with an unsubstituted phenyl group, alkoxyalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl or one of the radicals! , , or ! where m is 0 and n is 2 or 3, or m is 1 and n is 2,! p is 0 and q is 2 or 3, or p is 1 and q is 2, or also p is 2 or 3, and q is O,! Q is —CO— or —CH (ORa) -, Ra is hydrogen or alkyl and! Q 'represents —CO—; or ! W is —CH2—, and R2 is —NR7R8, —SR9, or —SO2R10; ! W is —O— or —S—, and R2 is alkyl, carboxyalkyl, alkoxycarbonylalkyl, hydroxyalkyl, alkoxyalkyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroarylalkyl; ! W represents —NR3—, and R2 represents hydrogen, alkyl, dialkylaminoalkyl, alkoxycarbonylalkyl, carboxyalkyl, carboxyalkyl substituted in its alkyl part with an unsubstituted phenyl group, hydroxyalkyl, alkoxyalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, cycloalkyl, cycloalkyl aralkyl, diphenylalkyl, heteroarylalkyl wherein said heteroaryl is monocyclic heteroaryl, —COR11 or —SO2R12; ! W represents -CH = CH-, and R2 represents