A COMBINATION OF COMPOUNDS THAT MAY BE APPLIED IN THE TREATMENT OF RESPECTIVE DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE DISEASES OF THE LUNG (COPD) AND ASTHMA

摘要

1. A pharmaceutical product containing in combination! (a) the first active ingredient, which is a compound of the general formula! ! where m is 0, 1 or 2; ! each R1 independently is halogen or cyano; ! R2 represents a hydrogen atom or methyl; ! R3 represents a C1-C4 alkyl group; and! R4 represents hydrogen or halogen; ! or a pharmaceutically acceptable salt thereof; and! (b) a second active ingredient that is a β2 agonist. ! 2. The composition according to claim 1, where R1 represents a halogen. ! 3. The composition according to claim 1, where R4 represents hydrogen or chlorine. ! 4. The product according to claim 1, where R4 represents hydrogen. ! 5. The composition according to claim 1, where R3 is methyl or ethyl. ! 6. The composition according to claim 1, where the first active ingredient is selected from! N- {2 - [((2S) -3 - {[1- (4-chlorobenzyl) piperidin-4-yl] amino} -2-hydroxy-2-methylpropyl) oxy] -4-hydroxyphenyl} acetamide,! N- {5-chloro-2 - [((2S) -3 - {[1- (4-chlorobenzyl) piperidin-4-yl] amino} -2-hydroxy-2-methylpropyl) oxy] -4-hydroxyphenyl} acetamide! N- {5-chloro-2 - [((2S) -3 - {[1- (4-chlorobenzyl) piperidin-4-yl] amino} -2-hydroxypropyl) oxy] -4-hydroxyphenyl} acetamide,! N- {5-chloro-2 - [((2S) -3 - {[1- (4-chlorobenzyl) piperidin-4-yl] amino} -2-hydroxypropyl) oxy] -4-hydroxyphenyl} propanamide or! N- {5-chloro-2 - [((2S) -3 - {[1- (4-chlorobenzyl) piperidin-4-yl] amino} -2-hydroxy-2-methylpropyl) oxy] -4-hydroxyphenyl} propanamide! or a pharmaceutically acceptable salt of any of them. ! 7. The product according to claim 1, where the first active ingredient is a salt selected from benzoate, furoate or hemifumarate salt of N- {2 - [((2S) -3 - {[1- (4-chlorobenzyl) piperidin-4- yl] amino} -2-hydroxy-2-methylpropyl) oxy] -4-hydroxyphenyl} acetamide. ! 8. The product according to claim 1, where the second active ingredient is formoterol or ind�