DERIVATIVES OF PHENYL AND PYRIDYL-1, 2, 4-OXADIAZOLONE WITH A PHENYL GROUP, METHODS FOR THEIR PRODUCTION AND THEIR APPLICATION AS PHARMACEUTICAL PRODUCTS

摘要

1. The compounds of formula I! ! formula I! where B represents C (R4) or N; ! R1 is H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O- (C0-C4) alkylene-H, (C0-C2) alkylene-O- (C0-C2) alkylene- (C3 -C6) cycloalkyl, SCH3, CN, where alkyl and alkylene are unsubstituted or mono-, di- or trisubstituted F; ! R2, R3, R4 are, independently,! H, halogen, (C1-C8) alkyl, (C0-C4) alkylene-O- (C0-C4) alkylene-H, SCH3, CN, where alkyl and alkylene are unsubstituted or mono-, di- or trisubstituted F; ! X represents O, S, S (O), S (O) 2, O-CH2, S-CH2, CH2-O, CH2-S; ! one of U and V represents N, the other represents S or O; ! W is a bond, (C1-C8) alkylene, (C2-C8) alkenylene, (C0-C6) alkylene- (C3-C6) cycloalkylene, (C3-C6) cycloalkylene- (C1-C6) alkylene, where alkylene and alkenylene and cycloalkylene are unsubstituted or mono-, di- or trisubstituted with OH and F; ! Y is a bond, O, S, S (O), S (O) 2, N (R6), and! R5 is H, (C1-C8) alkyl, (C0-C4) alkylene- (C3-C13) cycloalkyl, (C0-C4) alkylene- (C6-C14) aryl, (C2-C8) alkenyl, (C0- C4) alkylene- (C3-C15) heterocycloalkyl, (C0-C4) alkylene- (C3-C15) heterocycloalkenyl, (C0-C4) alkylene- (C5-C15) heteroaryl, (C0-C4) alkylene-CO- (C1 -C4) alkyl, (C0-C4) alkylene-CO- (C0-C4) alkylene- (C3-C13) cycloalkyl, (C0-C4) alkylene-CO- (C0-C4) alkylene- (C6-C10) aryl , (C0-C4) alkylene-CO- (C0-C4) alkylene- (C3-C15) heterocycloalkyl, (C0-C4) alkylene-CO- (C0-C4) alkylene- (C3-C15) heterocycloalkenyl, (C0- C4) alkylene-CO- (C0-C4) alkylene- (C5-C15) heteroaryl, SO2- (C1-C4) alkyl, SO2- (C0-C4) alkylene- (C3-C13) cycloalkyl, SO2- (C0- C4) alkylene- (C6-C10) Ryl, SO2- (C0-C4) alkylene- (C3-C15) heterocycloalkyl, SO2- (C0-C4) alkylene- (C3-C15) heterocycloalkenyl, SO2- (C0-C4) alkylene- (C5-C15) heteroaryl, CO-O- (C0-C4) alkylene- (C6-C10) aryl, CO-O- (C1-C4) alkyl, CO-O- (C0-C4) alkylene- (C3-C13) cycloalkyl, CO-O - (C0-C4) alkylene- (C3-C15) heterocycloalkyl, CO-O- (C0-C4) alkylene- (C3-C15) get�