DIAZEPANE DERIVATIVES, THEIR USE AS LFA INHIBITORS, METHOD OF CURING DISEASES CAUSED BY REACTION WITH LFA-1/ICAM-1

摘要

FIELD: chemistry.;SUBSTANCE: description is given of diazepane derivatives with formula I where R₁ stands for C₁-C₄alkyl, R₂ stands for unsubstituted C₁-C₄alkyl or C₁-C₄alkyl, substituted with quinolinyl, benzo[1,3]dioxolyl, phenyl, phenyl, substituted with 1-3 substitutes, chosen from a group, comprising halogen, halogen(C₁-C₄)alkyl, C₁-C₄alkoxy, cyano, amino, dimethylamino, carboxy(C₁-C₂)alkylcarbonylamino, amino(C₁-C₂)alkylcarbonylamino, C₂-C₄alkylenecarbonylamino, heterocyclylcarbonyl(C₁-C₂)alkylcarbonylamino, where heterocyclyl contains 6 atoms in the ring and 2 heteroatoms, chosen from N or N and O, R₃ stands for phenyl, substituted with one or two substitutes, chosen from a group, comprising halogen, halogen(C₁-C₆)alkyl, halogen(C₁-C₆)alkoxy, cyano, phenyl or aromatic heterocyclyl, containing 6 atoms in a ring and two nitrogen heteroatoms.;EFFECT: obtaining compounds with inhibiting effect on LFA-1/ICAM-1.;6 cl, 1 tbl