ANALOGUES OF QUINAZOLINE AS INHIBITORS OF RECEPTOR TYROSINE KINASES

摘要

FIELD: medicine.;SUBSTANCE: invention offers analogues of quinazoline of the formula I ;where A is bound at least with one of atoms of carbon in position 6 or 7 of the dicyclic ring; X represents N. A represents the group Q or Z including tautomeric group Z form where Q and Z, have the formulas resulted more low in which symbols and radicals, have the value specified in item 1 of the formula of the invention. R¹ represents phenyl, substituted -(G)_nOAr or -O(G)_nAr and where phenyl is unessentially replaced by halogen or C₁-C₁₀alkyl; where G represents C₁-C₄alkylene, n is peer 0 or 1. And Ar represents phenyl either pyridyl or thiazolyl where Ar is unessentially substituted by 1-2 substituents chosen from halogen or C₁-C₁₀alkyl; R² and R³ represent N. The bonds of the formula I are inhibitors of the receptor tyrosine kinases of type 1. The invention includes also a way of treatment of hyperproliferative diseases, such as a cancer, application of bonds of the formula 1 in manufacture of medical products and pharmaceutical composition on the basis of these bonds.;EFFECT: rising of efficiency of a composition and the method of treatment.;14 cl, 6 dwg, 63 ex