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Screening kit for molecules having anti-prion activity, screening method for molecules having anti-prion activity, and screened molecules
Screening kit for molecules having anti-prion activity, screening method for molecules having anti-prion activity, and screened molecules
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机译:具有抗pr病毒活性的分子的筛选试剂盒,具有抗-病毒活性的分子的筛选方法和被筛选的分子
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摘要
A kit used to screen agents for antiprion activity comprising a yeast (A) having the (PSI+) phenotype and an antibiogram, is new. Independent claims are also included for: (1) method of screening compounds for antiprion activity comprising culturing a lawn of (A) in vitro, applying test compounds by the antibiogram method, incubation for 2-4 days at 20-25 degreesC and analysis of the coloration of cell colonies; and (2) antiprion agents of formula (I). R' = hydrogen, amino or NHR2; R2 = 1-10C alkyl or alkylaminoalkyl; X = fluoro, chloro, bromo, iodo, trifluoromethyl, methylthio, methoxy, hydroxy, nitro, acetyl, aminocarbonyl, carboxy or COOR3; R3 = 1-4C alkyl; p and n = 0-2; and q = 0 or 1.
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