TREATMENT AND PREVENTION OF ISCHEMIC INJURY USING ACTIVATED PROTEIN C

摘要

Methods and compositions are provided for treating or preventing ischemic injury in a tissue flap in order to reduce the incidence of flap necrosis. Some compositions comprise one or more of an activated protein C (APC), a functional fragment of an APC, an APC mimetic compound, and a derivative of APC. Some methods comprise administering to a subject a therapeutically effective amount of an agent comprising one or more of an activated protein C (APC), a functional fragment of an APC, an APC mimetic compound, and a derivative of APC.