Methods of and Combination Therapies for Treating or Delaying the Onset of Dyskinesia

摘要

Methods of treating or delaying onset of levodopa-induced dyskinesia in an individual comprise administering to the individual an effective amount of mammalian target of rapamycin (mTOR) inhibitor. Methods of treating or delaying onset of dyskinesia in an individual, wherein the dyskinesia is induced by administration of a drug causing abnormal protein expression in striatal medium-size spiny neurons (MSNs), comprise administering to the individual an effective amount of mTOR inhibitor. Further, a combination therapy for an individual having Parkinson's Disease comprises levodopa or a precursor or functional analogue thereof and mTOR inhibitor.