Piridopirazinona derivatives that stimulate insulin secretion, Methods for obtaining them and their use in the treatment of Diabetes and Pharmaceutical compositions.

摘要

Prepare and use these pyrethrum derivatives to prevent and / or treat diabetes and related diseases. Item 1: a compound, in response to the general formula (1): the atom between X, y, Z and W is a nitrogen atom, while the other atom is a carbon atom, which is replaced by the alternative selected from the following substances: hydrogen, t; arilo, heteromorphic, cyclopropene, isopropyl, arilalquilo, ariloxiailquilo, arilalcoxi, tar, Alien, alien, alienPropyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl propyl Each of them can be replaced by one or more alternatives selected from t; R1 is: asphalt, tar / axing, cyclopropyl, isocyclopentyl, cyclopentadiol, isocyclopropylene glycol, isocyclopentadiene methanol, isocyclopentadiol, isocyclopentadiene glycol, isocyclopentadiol, cyclopentadiene glycol, r3r4n tar, arilo, Straight, straight, straightEach of them can be replaced by one or more alternatives selected from t: hydroxyl group, uncle, halogenation, cyanogen, trifluoromethyl toxi, trifluoromethyl, carboxi, carboximetilo, carboxietilo, hydrocarbyl, cyclopentyl, alcox, rental, arilo, arilsulfonilalquilo, ariloxi, arilalcoxi, NR3, azido, nitro, guanidini, Amidino, photosono, oxo, carbamoilo, acquilsulfonilo, asphalt, asphalt, sF5, two t groups can form a kind of methylenedioxy; R3 and R4 are selected from the following substances respectively; hydrogen, lower asphalt, cyclopentadiene, isocyclopentadiene, arilo, isopropene;R3 and R4 can also form an isomerized ionomer, which can include one or more isomerized atoms selected from n, O and S; R3 and R4 can be independently replaced by one or more substitutes selected from t; and their racemization, tautomeros, enabler, dieteros and other forms, Polymers, polymers and mixtures thereof, and acceptable salts for pharmaceutical use.