METHOD FOR THE PREPARATION OF MORPHINE COMPOUNDS.

摘要

The present invention relates to a method for the preparation of morphine compounds comprising a low content of ¿,ß-unsaturated compounds, which comprises the steps of: (i) bringing the crude morphine compound into contact with a base, at a pH of greater than 13, under conditions which make possible the Michael addition reaction on the ¿,ß-unsaturated compound(s)present; (ii) separating the morphine compound from the reaction mixture; and(iii) if appropriate, separating the addition product formed, from the morphine compound. It also relates to a composition comprising at least 99% by dry weight of morphine compound, or of a pharmaceutically acceptable salt thereof, and an ¿,ß-unsaturated compound in a content of less than 100 ppm.