Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human box-A of HMGB1 to prevent and/or antagonize pathologies induced by HMGB1

摘要

Provided is a mutant polypeptide variant of the human high affinity binding domain Box-A with a specified amino acid sequence or a biologically active fragment thereof, wherein said polypeptide variant exhibits an increased resistance to the proteolytic activity of proteases compared to the wild type. The compositions are useful for treatment of pathological conditions mediated by activation of the inflammatory cytokine cascade.