USE OF POLYPEPTIDES OBTAINED THROUGH SYSTEMATIC MUTATIONS OF SINGLE AMINO ACIDS OF HUMAN AND NON-HUMAN BOX-A OF HMGB1 TO PREVENT AND/OR ANTAGONIZE PATHOLOGIES INDUCED BY HMGB1

摘要

The present invention relates to polypeptide variants of the HMGB-1highaffinity binding domain Box-A (HMGB1 Box-A) or to a biologically activefragment of HMGB1 Box-A, which are obtained through systematic mutations ofsingle amino acids of the wild-type HMGB1 Box-A protein and which show anincreased resistance to proteases and which are therefore characterized bymore favourable pharmacokinetic and pharmacodynamic profiles. Moreover, thepresent invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated withextracellular HMGB1.