NUCLEIC ACIDS AND ALLERGENS OF OLIVE POLLEN OF DEFINED OLIVE VARIETIES AND APPLICATIONS.

摘要

The invention relates to nucleic acids and allergens of olive tree pollen of defined olive tree varieties and to the applications thereof. Nucleic acids that encode peptides or fragments of same have been isolated, characterised and identified, said nucleic acids comprising at least one epitope of allergen Ole e 1 or of allergen Ole e 2 of olive tree pollen of defined olive tree varieties. Said peptides, which possess one or more allergenic epitopes of the major allergens of olive tree pollen, have allergenic activity and can be used in the diagnosis and treatment of an allergy to olive tree pollen. The allergenic activity of the aforementioned peptides or fragments of same can be modulated with the introduction of suitable modifications in order to produce hypoallergenic or hyperallergenic variants. In addition, the use of specific recombinant allergens of defined olive tree varieties enables individual reactivity profiles to be determined for each patient and personalised immunotherapies to be produced.