RIGIDIZED TRIMETHINE CYANINE DYES

摘要

Disclosed are analogues of trimethine cyanine dyes which are useful forimparting fluorescent properties to target materials by covalentand non-covalent association. The compounds have general formula (2)optionally substituted by groups R2 - R9 wherein groups R6, R7,R8 and R9 are attached to the rings containing X and Y or, optionally areattached to atoms of the Z a and Z b ring structures and groups R1- R9 are chosen to provide desired solubility, reactivity andspectralproperties to the fluorescent compounds; A is selected from O, S andNR11 where R11 is the substituted amino radical (a), where R' is selected fromhydrogen, a C1-4 alkyl and aryl and R" is selected fromC1-18 alkyl, aryl, heteroaryl, an acyl radical having from 2-7 carbon atoms,and a thiocarbamoyl radical; Z a and Z b each represent a bondor the atoms necessary to complete one, two fused or three fused aromaticrings each ring having five or six atoms, selected from carbonatoms and, optionally, non more than two oxygen, nitrogen and sulphur atoms.