METHODS FOR PRODUCING POROUS TRICALCIUM PHOSPHATE-BASED GRANULES, AND BONE GRAFT MATERIALS USING THE SAME

摘要

The present invention relates to a method for producing porous tricalcium phosphate-based granules, and to a method for producing bone graft materials using the porous tricalcium phosphate-based granules produced thereby. The granules according to the present invention are made through a process comprising repeatedly adding tricalcium phosphate-based powder to a tricalcium phosphate-based slurry while rotating a mixer having a cutting blade, and adjusting the sizes of the tricalcium-based granules, without using porous precursors, dispersants or organic solvents. Further, the method for producing bone graft materials according to the present invention comprises submerging the porous tricalcium-based granules produced by the above-described process in an osteogenic protein solution to bind osteogenic proteins to the pores of the porous tricalcium phosphate-based granules, and freeze-drying the resultant materials.