Preparation method of porous Tricalcium phosphate-based granules and preparation method of functional bone graft

摘要

The invention of porous tricalcium phosphate granules based method and the method of functional bone graft material using the same of such, a method of preparing a porous tricalcium phosphate based granules according to the invention without the use of a pore precursor, the dispersion medium, an organic solvent, while rotating the mixer, with a blade, the addition of tricalcium phosphate-based powder in the tricalcium phosphate-based slurry repeating the steps to form a tricalcium phosphate-based granules, characterized in that for adjusting the size of the tricalcium phosphate-based granules. In addition, functional bone grafting material of the manufacturing method according to the invention combines the pores of the porous tricalcium phosphate-based bone morphogenetic protein by immersing the granules in a porous tricalcium phosphate-based bone granules to form a protein solution prepared by the method of the present invention It is characterized by freeze-drying. Porous tricalcium phosphate-based method of producing granules of the present invention may be the process is simple, creating a porous tricalcium phosphate based granules is harmless to the human body, in a manufacturing process (in-situ) the size of the porous tricalcium phosphate based granules in It can be easily adjusted. Further, the bone graft material production method of the present invention is to minimize damage to the bone morphogenetic protein, specifically, an inert protein to reduce the potential of the water by completely removing water by freeze-drying, the growth of bacteria can be suppressed.