METHOD OF GENETICAL VARIABILITY DETECTION IN ANIMAL CELL CULTURE OF DIFFERENT PASSAGE RATE

摘要

FIELD: medicine.;SUBSTANCE: invention can be used for genomic changes detection in cell lines of mammals, occurring within cell cultures passages number expansion, necessary for augmentation of materials for medical purposes. Test-system is based on RAPD-PCR analysis of RNA. Method was used for control of human tissue stromal cells and human fibroblast cultures of different cultivation continuance.;EFFECT: invention allows highly sensible control of genome's stability in cell cultures of different cultivation continuance.;4 cl, 6 dwg, 1 tbl, 2 ex