Genetic construct and its use, vertebrate animal cell, methods of altering the vertebrate animal cell phenotype and gene therapy in genetically modified vertebrate, animal and murine animal

摘要

"GENETIC CONSTRUCTION AND ITS USE, VERTEBRATE ANIMAL CELL, PHENOTYPE CHANGE METHODS OF A VERTEBRATE ANIMAL AND GENETIC THERAPY CELL, ANIMAL AND ANIMAL MODULE IN GENUALLY MODIFIED INVENTION" , promoting or otherwise facilitating a change in the phenotype of an animal cell or group of animal cells including an animal encompassing said cells. Modulation of phenotypic expression is conveniently carried out via phenotypic manipulation by means such as reducing translation translation from transcript to proteinaceous product. The ability to induce, promote or otherwise facilitate silencing of expressible gene sequences provides a means of phenotype modulation, for example in the medical, veterinary and animal husbandry industries. The expressible gene sequences contemplated by the present invention include not only genes normally residing in a particular animal cell (i.e. indigenous genes) but also genes introduced by recombinant means or through infection by pathogens such as viruses.