METHOD FOR PRODUCING VIABLE BACTERIAL PREPARATION

摘要

PPROBLEM TO BE SOLVED: To provide a method capable of producing a viable bacterial tablet, in a viable bacterial preparation containing viable bacteria as an active ingredient, wherein the tablet has high bacterial viability during production, shows low extinction of bacteria after preparation, has high tablet hardness and low friability, and has good collapsibility. PSOLUTION: The method for producing a viable bacterial preparation includes the steps of: (1) granulating an excipient composition (I) containing starch to obtain a granule; (2) mixing the granule, a powder composition (II) containing disaccharide, polysaccharide, and calcium carbonate, and viable bacteria to obtain a viable bacteria-containing composition; and (3) compression molding the viable bacteria-containing composition at a tableting pressure of 10 to 20 kN/cmSP2/SP. The amount of the powder composition (II) mixed in the step (2) is 0.15 to 1.0 pts.mass based on 1 pt.mass of the granule. PCOPYRIGHT: (C)2011,JPO&INPIT