Therapeutic agent and treatment method for atopic dermatitis in dogs

摘要

PROBLEM TO BE SOLVED: To obtain the subject medicine capable of treating both dogs and cats suffered from immunopathy and of preventing such diseases, by including canine interleukin 12 where specific amino acid sequences form a heterodimer. SOLUTION: This medicine contains canine interleukin 12 which is obtained by forming a heterodimer from (A) an amino acid sequence of formula I or formula II or part thereof and (B) another amino acid sequence of formula II or formula IV or part thereof. The canine interleukin 12 can be obtained using e.g. the gene recombinant technique, or, using animal cells simultaneously transduced with the respective DNA sequences of the components A and B, or insect cells or larvae therefrom infected with baculovirus simultaneously containing these DNA sequences. It is preferable that this medicine is administered to dogs or cats through injection.