CONJUGATES OF 19F MR IMAGING TRACERS FOR USE IN MULTI-CHROMIC MRI IMAGING

摘要

Compositions for producing multi-chromic (“color”) magnetic resonance images (MRI). The compositions for use as MRI imaging agents include a magnetic resonance imaging tracer having a signal emitter, such as a ¹⁹F imaging tracer (¹⁹FIT), conjugated with a magnetic signal modulator, such as a paramagnetic functional group or a paramagnetic ion. The ¹⁹FIT and the signal modulator (M) are joined covalently by a chelator such as DOTA, forming a nanometer-sized fluorinated paramagnetic complex ¹⁹FIT-DOTA-M. Other signal emitters, such as ³¹P imaging tracer (³¹PIT), can also be modulated using this strategy (i.e., ³¹PIT-DOTA-M) to generate multi-chromic ³¹P MRI or MRS.