Biodistribution and pharmacokinetics of a macromolecular conjugated anticancer drug: assessment with ~19F NMR imaging

摘要

3-aminobenzamide (3-ABA) is a potent agent, which inhibits the repair of radiation-induced DNA strand breaks (1), and thus enhances the antitumor activity of radiotherapy (radiosensitization). The effective clinical use of radiosensitizers, requires the development of drug targeting systems and the investigation of imaging techniques to noninvasively monitor the biodistribution of the agent.