SLEEP-WAKE DISORDERS TREATMENT

摘要

TREATMENT OF SLEEP-SURVEILLANCE DISORDERS. The present invention is directed to a method of treating excessive daytime sleepiness (EDS) in an individual, comprising the step of administering a therapeutically effective amount of a compound of Formula (1): Formula (1) or a pharmaceutically acceptable salt or ester. where Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, selected halogen of F, Cl, Br and 1, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl and thioalkoxy containing from 1 to 3 carbon atoms; x is an integer from 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R 1 and R 2 may be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms. carbon; R 1 and R 2 may be joined together to form a 5 to 7 membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups wherein the cyclic compound may comprise from 1 to 2 atoms of nitrogen and from 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.