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TREATMENT OF SLEEP-WAKE DISORDERS

机译:治疗睡眠症状

摘要

This invention is directed to a method of treating Excessive daytime Sleepiness (EDS) in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the ox en atom.
机译:本发明涉及一种治疗受试者中过量的白天嗜睡(EDS)的方法,包括施用治疗有效量的式(I)化合物:式(I)或其药学上可接受的盐或其酯Rx是选自氢,1至8个碳原子的低级烷基,选自F,Cl,Br和I的卤素,含有1至3个碳原子,硝基,羟基,三氟甲基和硫烷氧基的含有1至3个碳原子的卤素氧基到3个碳原子; x是1到3的整数,当x为2或3时,r可以相同或不同; R1和R 2可以彼此相同或不同,并且独立地选自氢,1至8个碳原子,芳基,芳基烷基,芳基烷基的芳基,芳基烷基为3至7个碳原子的基团; R1和R2可以连接以形成5至7元杂环被选自氢,烷基和芳基的构件,其中环状化合物可包含1至2个氮原子和0至1氧原子,其中氮原子不彼此直接连接或与氧气原子直接连接。

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