SYMBIOTIC BACTERIA AS MEDIATORS FOR THE TRANSMISSION OF SIGNALS IN THE MAMMALIAN - HOST

摘要

Genetically engineered cells and microorganisms are provided to prevent or alleviate the course of disease through signal transmission by a genetically modified population of bacteria. Also provided are therapies using these cells and microorganisms to prevent or alleviate the course of diseases. These cells or microorganisms can be modified using genetic engineering so that they express the signal and can be used to interrupt the invasive pathogen associated with signal transduction of virulence. These cells or microorganisms can be used to provide signal-dependent expression of the desired gene in order to interrupt, prevent and / or alleviate the course of the disease in a mammal, for example, a disease caused by parasites, an infectious disease, an autoimmune disease and a genetic disorder.