Commensal bacteria as signal mediators within a mammalian host

摘要

#$%^&*AU2015271866A120160121.pdf#####ABSTRACT Genetically engineered cells and microorganisms are provided for preventing or ameliorating diseases through genetically engineered quorum signaling. Therapeutic methods for using the cells and microorganisms to prevent of ameliorate diseases are also provided. The genetically engineered cells or microorganisms can be engineers to express a signal and used to interrupt the signaling-dependent virulence of an invading pathogen. The cells or microorganisms can be used to provide signaldependent expression of a desirable gene in order to interrupt, prevent, and/orameliorate a disease of mammals, such as parasitic diseases, infectious diseases, autoimmune diseases and genetic disorders.