MUTATIONS IN THE INFLUENZA A VIRUS NS1 GENE AND USE THEREOF

摘要

NS1 variant polypeptides, proteins or functional fragments thereof aredescribed which haveuseful properties for increasing viral protein synthesis, IFN induction, andIFN resistance. TheNS1 variant polypeptides, proteins or functional fragments comprise asubstitution in the aminoacid sequence of the wild type NS1 protein at a position corresponding to Asp-2, Val-23, Leu-98,Phe-103, Ser-103, Met-106, Met-124, Asp-125, Val-180, Val-226 or Arg-227, orcombinationsthereof expressed alone or in infectious virus.