Diaza-spiropiperidine derivatives as inhibitors of glycine transporter 1 and glycine transporter 2

摘要

The present invention relates to compounds of formula (I) wherein A-B is CH-CH,-CH-O-, O-CH, CH-S, -S-CH-, CH-C(O)-,C(O)-CH-, .-N(R)-CH- or -CH-N(R)-;R is lower alkyl, lower alkenyl, cycloalkyl, or is aryl, optionallysubstituted by one or two substituents, selected from the group consisting ofhalogen, cyano, lower alkyl, CF, OCFor lower alkoxy,or is heteroaryl, optionally substituted by one or two substituents selectedfrom the group consisting of halogen, lower alkyl, CF or lower alkoxy;R is lower alkyl, cycloalkyl, or is aryl, optionally substitutedby one or two substituents, selected from the group consisting of halogen, loweralkyl, CF, lower alkoxy, or is heteroaryl, optionally substitutedby one or two substituents, selected from the group consisting of halogen, loweralkyl, CF, lower alkoxy, or is heteroaryl, optionally substitutedby one or two substituents, selected from the group consisting of halogen, loweralkyl, CFor lower alkoxy; R is hydrogen, lower alkylor benzyl; Ris hydrogen or benzyl; n is 0, 1 or 2; and to pharmaceuticallyavailable salts thereof. The compounds of formula I may be used in the treatmentof neurological and neuropsychiatric disorders.