A pharmaceutical composition. The composition has a plurality of controlled release particulates. Each particulate includes a coating layer and a core partially coated with the coating layer, in which the core contains a water-insoluble drug 5-80 wt.% and a first polymer 0.2-80 wt.% and the coating layer contains the water-insoluble drug 0-50 wt.% and a second polymer 0.2-50 wt.%. Each of the first and second polymers, independently, is a water-insoluble polymer, an enteric polymer, or a combination thereof. A method of making the composition is also disclosed herein.
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