STATIONARY PHASE AND COLUMN USING CUCURBITURIL BONDED SILICA GEL, AND SEPARATION METHOD OF TAXOL USING THE COLUMN

摘要

Provided are a stationary phase and a column using a cucurbituril-bound silica g el, and a method of separating taxane using the column. The taxane separation meth od includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represen ted by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formul a 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; ap plying the taxane-containing solution to the column; supplying a mobile-phase solvent t o the column to obtain a taxane extract from the column; and purifying taxane from the t axane extract. Therefore, highly purified taxane can be separated from a low-purity cr ude taxane extract.