DNA MICROARRAY BASED IDENTIFICATION AND MAPPING OF BALANCED TRANSLOCATION BREAKPOINTS

摘要

Methods for detecting and mapping chromosomal rearrangements associated with various diseases using comparative genomic hybridization are disclosed. Included are methods to identify translocation partners of known genomic loci and to determine translocation breakpoints. These methods may be used in the prognosis, diagnosis, and determination of predisposition to diseases that involve chromosomal rearrangements.