PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DISEASES CAUSED BY THE NUCLEAR EXPORT OF GSK3, INCLUDING A COMPOUND FOR INHIBITING THE NUCLEAR EXPORT OF GSK3

摘要

The present invention relates to a pharmaceutical composition for treating or preventing disease caused by the nuclear export of GSK3, including a compound for inhibiting the nuclear export of GSK3, and more specifically, to a pharmaceutical composition for inhibiting the growth or metastasis of cancer cells and including a novel compound for inhibiting the nuclear export of GSK3, and to a pharmaceutical composition for treating autoimmune diseases. According to the present invention, a composition for inhibiting the onset and progression of a disease caused by a decrease in GSK3 concentration in a cell nucleus through the nuclear export of GSK3 is provided. The compound according to the present invention is useful for treating or preventing various diseases by inhibiting the nuclear export function of GSK3 by Axin and increasing the concentration of GSK3 in the nucleus.